Standardized Method for Extraction and Purification of Forskolin from the Roots of Coleus forskohlii
The present invention discloses a standardized method for isolation and purification of Forskolin from the roots of Coleus forskohlii belonging to the Labiatae (Lamiaceae) family. The method is a selective extraction by organochlorine solvent and purification by column chromatography and crystallization. Forskolin, extracted from roots, is a bronchodilator, cardiotonic in the treatment of congestive heart failure, glaucoma therapy; antihypertensive ;remedy for metastatic condition and thrombosis. Since total synthesis of Forskolin is not a practical route for meeting the current global demands of the compound, the latter option is a need of hours.
Sector: Pharmaceuticals
Country: India
Area of Application: Forskolin is a compound that has been identified as a source of therapeutic potential and high commercial value compound, used as anti-glucoma, anti-platelet, bronchospasmolytic, cardiotonic, arterial relaxant, anti-histamatic, anti-aging, anti-allergic and anti-hypotensive
Keywords: Forskolin, Coleus forskohlii, Extraction, Isolation and purification, HPLC assay.
Advantages: 1). The product is from natural sources , 2.) The whole process of extraction and purification is eco-friendly than synthetic route. 3). Expensive and hazardous chemicals are not in use any where in the process. 4). As the product is from herb used in traditional system of medicines, it is non- toxic. The product (i.e. Forskolin) isolated from C. forskohlii does not have any unknown/ foreign toxic compound /impurity, while in case of synthetic Forskolin, traces of unknown impurity may lead to a fatal threat. 5). A standardized extraction and purification methodology available.
Environmental aspects: Healthcare
Development Status: Laboratory Model
Legal Protection: Patent
Technical specifications: Free flowing powder with defined contents.
Transfer Terms: Consultancy , Technical Services , Technology Licensing , Research Partnerships
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