Nanopatch Sensor in Cell Membrane
The present technology provides a real-time novel cellular platform which may be used for detecting occurrence of cellular biochemical processes that involve membrane perturbation or take place at membrane surfaces. The cellular platform i.e a chemical construct (nanopatch) comprising polydiacetylenes and lipids may be assembled within the cell membrane of living cells, and that said construct retains its ability to undergo its characteristic chromatic (red to blue) transition and associated fluorescent emission in live cells in response to various perturbing agents and conditions. It has further been unexpectedly found that following insertion of said construct into the cell membrane of living cells, the viability of said cells is retained for a period of time that is sufficient to permit the use of said cells as a system for detecting and/or quantifying biochemical events that lead to structural and morphological changes in the cell membrane and/or other processes occurring at the surface of the cell membrane.
Sector: Pharmaceuticals
Country: India
Area of Application: Biotech industry and medical industry.
Keywords: cellular assay, nano patch, cell membrane, cell activity
Advantages: Useful for real-time investigations of cellular processes. Rapid screening of pharmaceutical compounds. Chromatic nanopatch can be attached to many cell types from different sources. Detection of compounds in real-living cell scenario.
Environmental aspects: Not Applicable
Development Status: Laboratory Model
Legal Protection: Patent
Technical specifications:
Transfer Terms: Technology Licensing
Target Countries:
Estimated cost (US$):
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Contact Person: SkyQuest Technology Consulting Pvt. Ltd.
Address: 501, Krishna Complex, Opp. Devashish School, Bodakdev
City: Ahmedabad
Country: India
Zip/Pin Code: 380054