Methods for preparation of novel a-Hydrazino-a,ß-unsaturated nitro compounds for amino acids synthesis
The main objective of the present invention is to provide commercially viable single pot process for the preparation of a-hydrazinoa, ß-unsaturated nitro compounds from, ß-unsaturated nitro compounds in high yields.The technology also suggest a process to obtain the said nitro compounds, a conjugated nitroalkene was reacted with an azo compound in the presence of a cyclic or acyclic amine as catalyst and a-hydrazinoa, ß-unsaturated nitro compound produced (Scheme). During a standard reaction procedure a solution of nitroalkene and azo compound is stirred at room temperature until the reaction goes to completion. The reaction mixture is then diluted with aqueous acid and the aqueous layer is extracted with a suitable organic solvent. Finally, the combined organic layers are concentrated to yield a substantially pure a-hydrazino-a, ß-unsaturated nitro compound. This reaction is carried out in the presence or absence of a range of solvents (e.g. methanol, chloroform, benzene, acetone etc.) which do not react with either of the coupling partners. Several a-hydrazino- a, ß-unsaturated nitro compounds were prepared to establish the process.
Sector: Pharmaceuticals
Country: India
Area of Application: Pharma industry.
Keywords: aminoacids,synthesis
Advantages: Single pot method.Inhibits cervical cancer cell proliferation. High yield. Simple method. Commercially viable method. Wide application.
Environmental aspects: Not Applicable
Development Status: Laboratory Model
Legal Protection: Patent
Technical specifications:
Transfer Terms: Technology Licensing
Target Countries: India
Estimated cost (US$):
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