A Novel Capsul Having Faster Disintegration & Dissolution Property
The present technology suggests a novel hard gelatin capsule shell and method of preparation of the same. Method by which modified hard gelatin capsule shell is prepared, do not show adverse effect on drug dissolution or on aging. Modifications in conventional hard gelatin capsule are proposed to nullify the slowing down of dissolution of gelatin shell on aging. Such modified capsule releases the contents without any hindrances.In order to facilitate penetration of dissolution medium in hard gelatin capsule and subsequent drug dissolution, a hole is drilled in hard gelatin capsule shell and later the hole is sealed with film former, which is pharmaceutically acceptable, that does not undergo cross-linking. The steps involved in the process are: Preparing a hole (opening) of 0.5 mm diameter in "body" part of hard gelatin capsule. Sealing/coating the hole by pouring technique or spray coating by using the dispersion containing. 5% Hydroxypropyl Methylcellulose (HPMC), 10% glycerol and quantity sufficient of ethyl alcohol on the inner surface of the capsule and keeping the mixture for 10 seconds in contact with shell (cap and body). Inverting the capsule parts up and down till the internal surface of capsule shell is uniformly covered and drying the capsule shells after draining off the dispersion. Finally joining the separated capsule parts(cap and body).
Sector: Medical Technologies
Country: India
Area of Application: Medical industry.
Keywords: Disintegration & Dissolution Property,Hydroxypropyl methylcellulose.
Advantages: Arrest Cross-linking of gelatin capsule shell. Better water penetration. Cost effective. Better disintegration and dissolution. Rapid onset of action. Vegitarian Capsule.
Environmental aspects: Not Applicable
Development Status: Laboratory Model
Legal Protection: Patent
Technical specifications:
Transfer Terms: Technology Licensing
Target Countries: India
Estimated cost (US$):
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Contact Person: SkyQuest Technology Consulting Pvt. Ltd.
Address: 501, Krishna Complex, Opp. Devashish School, Bodakdev
City: Ahmedabad
Country: India
Zip/Pin Code: 380054