A Novel Composition for Peptic Ulcers
The present technology provides a pharmaceutical composition comprising the therapeutically effective amount of the compound Oenothein C (bioactive fraction of plant Woodfordia fruticosa) optionally along with one or more pharmaceutically acceptable carriers, additives, lubricants and diluents. More particularly, it relates to a method of treating peptic ulcer diseases (including gastric ulcer, duodenal ulcer and also gastritis, gastro esophageal reflux disorder (GERD)) in a human subject using the said pharmaceutical composition. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values of Oenothein C, Clarithomycin, Amoxicillin and Metronidazole in different strains of H.pylori is tabulated in the below given table. Sample MIC (µg/ml) MBC (µg/ml) Strains Strains 80 A ATCC 43504 ATCC 49503 NCTC 26695 ATCC 43629 80 A ATCC 43504 ATCC 49503 NCTC 26695 ATCC 43629 Oenothein C 25 25 6.25 12.5 25 50 >50 50 25 >50 Clarithomycin 0.02 0.025 0.006 0.063 0.050 0.04 0.05 0.013 0.1 0.1 Amoxicillin 0.02 0.025 0.013 0.1 0.025 0.08 0.05 0.05 <1.0 0.05 Metronidazole 12.5 50 1.56 1.56 1.56 >100 100 12.5 10 6.25 ADVANTAGE TO THE LICENSEE TO THE ENDUSER Inhibition of gastric proton pump by the compound oenothein C is much stronger than standard medicine omeprazole (about 20 times). It can be administered orally, intramuscularly and intravenously. Has dual function: as anti-gastric proton pump and anti-Helicobacter pylori activity. Can be taken in various form such as powder, injectable, syrup, capsule and tablets. Useful against many types of peptic ulcers (i.e. gastric, duodenal, gastritis and gastro esophageal reflux disorder (GERD). Does not show any toxic effect at the single dose level upto 250 mg/kg body weight.
Sector: Medical Technologies
Country: India
Area of Application: medical industry.
Keywords: peptic ulcers,Oenothein C,Clarithomycin, Amoxicillin, Metronidazole.
Advantages: Inhibition of gastric proton pump by the compound. Oenothein C is much stronger than standard medicine Omeprazole (about 20 times). Can be administered orally, intramuscularly and intravenously. Has dual function: as anti-gastric proton pump and anti-helicobacter pylori activity. Can be taken in various form such as powder, injectable, syrup, capsule and tablets. Useful against many types of peptic ulcers (i.e. gastric, duodenal, gastritis and gastro esophageal reflux disorder (GERD). Does not show any toxic effect at the single dose level upto 250 mg/kg body weight.
Environmental aspects: Not Applicable
Development Status: Laboratory Model
Legal Protection: Patent in Progress
Technical specifications:
Transfer Terms: Technology Licensing
Target Countries: India
Estimated cost (US$):
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Country: India
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