Tumor Specific Markers for Detection and Treatment of cancer
Human UGT-X, an integral membrane enzyme, is involved in biotransformations of a wide variety of endogenous compounds, such as fatty acids, retinoids, steroid compounds and many drugs and xenobiotics. Glucuronidted substrates usually become biologically inactive and, due to the increased solubility, are excreted from tissues. The UGT-X messenger RNA is not present in normal ovarian tissue and nonmalignant ovarian fibroma, although is highly expressed in mucinous adenoma (LMP tumor) and in endometrioid carcinoma. The endogenous synthesis of fatty acids is a characteristic feature of tumor cells, as opposed to normal cells, and is a significant source of fatty acids for growth and production of fatty acid derivatives that promote cell proliferation of these cells. Researchers have shown that ectopic expression of UGT-X protein leads to growth arrest of human ovarian tumor cells. The novel feature of this technology is that tumor cells can be sequestered in growth by starvation of fatty acids, major substrates for the biosynthesis of membranes and secondary messengers. Active UGT-X proteins expressed in tumor cells can be used to decrease cell proliferation and in combination with other treatments may be used to treat various cancers. Additionally the UGT-X messenger RNA and/or the protein and/or the activity can be used as a tumor specific marker in diagnostic procedures.
Sector: Pharmaceuticals
Country: India
Area of Application: Medical diagnosis
Keywords: Cancer, LMP tumor
Advantages: Can be used as a tumor specific marker in diagnostic procedures. Provides new method of cancer detection Sequesters tumor cell growth by over expression. Useful in cancer treatment
Environmental aspects: Not Applicable
Development Status: Laboratory Model
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Technical specifications:
Transfer Terms: Technology Licensing
Target Countries: India
Estimated cost (US$):
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Contact Person: SkyQuest Technology Consulting Pvt. Ltd.
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Country: India
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