Treatment and Prevention of Fungal and Bacterial Infections
The present technology provides novel liner antimicrobial peptides for the treatment and prevention of a panel of opportunistic fungal and bacterial pathogens. The natural occurring antimicrobial peptides (isolated from all virtually all the kingdoms and phyla) are not only lethal to a broad spectrum of pathogens but also have a unique low tendency for resistance development. These peptides are the integral part of the host defense system and are supposed to be strategically evolved against the common infections of the host cells. Consequently, these are specifically toxic to the pathogens and are able to differentiate between host and microbial cells. This specific recognition may be governed by the difference in the membrane composition and hence charge, membrane asymmetry, transmembrane potential, and specific receptor binding. The antimicrobial mechanism of action of these peptides includes either formation of multimeric pores in the cell membranes leading to cell lysis or interaction with the RNA or DNA after penetration into the cell. It is expected that development of these peptides as ideal anti-infective agents will add to already existing armament for the suppression as well as radical cure of the various opportunistic fungal and bacterial infections.
Sector: Pharmaceuticals
Country: India
Area of Application: bacterial infections,specifically toxic
Keywords: bacterial infections
Advantages: Has broad-spectrum activity of antibacterial and antifungal effects Causes rapid onset of pathogen killing Potentially low levels of induced resistance due to peptide nature of drug Elimination of cyto-toxic side effects
Environmental aspects: Not Applicable
Development Status: Laboratory Model
Legal Protection: Patent in Progress
Technical specifications:
Transfer Terms: Technology Licensing
Target Countries: India
Estimated cost (US$):
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Contact Person: SkyQuest Technology Consulting Pvt. Ltd.
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City: Ahmedabad
Country: India
Zip/Pin Code: 380054